Haisi kungoita maitiro akaomarara, asi chirwere chitsva chisingawanzozivikanwa icho chave kuzivikanwa uye chinogona kurapwa.
imwe yakawanikwa itsva isingawanzo genetic chirwere, uye aya mashoko akanaka. Dambudziko nderekuti chirwere ichi sezviri pachena chakafanana nechimiro zvakanyanya chisimbwa. Izvi zvinogona kutungamirira kukuongororwa kusina kururama uye naizvozvo kusashanda kurapwa. Chingave chakaita senge allergies chaive panzvimbo a chimiro che immunodeficiency. Ngationei kuti chirwere ichi chii.
Kuwanikwa kweiyo isingawanzo genetic chirwere
Kunyanya, iyo itsva genetically based primary immunodeficiency. Yakaonekwa nemubatanidzwa wevazhinji vevaongorori vepasi rose inorongwa neBritish Columbia Children's Hospital muVancouver, Canada, iyo chikamu chePediatric Hospital Infant Jesus of Rome. Iyo Consortium yakazvarwa kubva pakudikanwa kwekugovana ruzivo rwekurapa kwevanhu vane hunhu hwekiriniki hwakafanana hunoenderana neiyo genetic defect.
Vakaburitsa zvakawanikwa mu Zvinyorwa zveExpimental Medicine. Ongororo iyi yakaita kuti zvikwanise kuziva chirwere ichi chisingawanzo genetic, icho chinogovera zviratidzo nemhando yakaoma yeallergy uye iyo chete 20 zviitiko zvinozivikanwa pasi rese.
Chitsva chisingawanzo genetic chirwere, chidzidzo
Chidzidzo chepasi rose chakabvumira kuzivikanwa kwechirwere chisingawanzo genetic chakaitwa muvana gumi nevatanhatu kana vechidiki vechidiki vakapa mufananidzo wakafanana wekiriniki unoratidzirwa nekusawirirana kwakanyanya, hutachiona hunogara huchiitika, atopic dermatitis uye asima.
Tsvagiridzo yakakwanisa kuona shanduko mu STAT6 gene, iyo inoita basa rakakosha mukusiyaniswa kwerudzi rwesero re immune system, T lymphocytes, inonyanya kubatanidzwa mukuonekwa kweallergic reaction. Kunyange zvazvo zviratidzo zvikuru zvinogona kuenzanisa chimiro chakakomba chekusagadzikana, kana pane kuchinja mukushanda kwejeni iri, kunewo matambudziko mukugadzirisa kwekudzivirira kwemuviri, iyo nyanzvi dzinotsanangura sekudzivirira kwekudzivirira muviri.
Migumisiro yekuwanikwa uku
Kuzivikanwa kwechirwere chisingawanzoitiki chemajini uye zvikonzero zvayo, zvakanyatsobatanidzwa nemaitiro emajini, zvakatobvumira nzira itsva dzokurapa kuti dzitevedzwe zvinobudirira. Kunyanya, the nyanzvi kubva kuBambino Gesù muRoma, iyo chete nzvimbo yeItaly iyo yakatora chikamu muchidzidzo, yakatarisira kliniki yekutevera-up, iyo immunological characterization yemumwe we16 vechidiki zvikuru vakaumba boka uye zvidzidzo zvekushanda, kujekesa maitiro ekutanga kwekutanga. immunodeficiency.
Vakatevera mwana kubva pamakore ekutanga ehupenyu, vachiwana kuongororwa kwakajeka mukukura. Kuzivikanwa kweiyo genetic zvikonzero zvine chekuita nemimwe mifananidzo yekiriniki inobvumira a kutanga diagnostic,iyo inokosha pakugadzirisa panguva nekuderedza kushandiswa kwemishonga ye cortisone inokonzera migumisiro. Uyezve, kunzwisisa mashandiro ari pasi peiyo immune dysregulation phenomena inovhura mukana wekushandisa mishonga yemunhu kune vana vane allergies yakaoma.
Chirwere chitsva ichi chinogona kurapwa sei?
“Vana vane zviratidzo zvakakomba zvekusawirirana nenhengo dzemuviri vanogona kukanganiswa nekukanganisa kwekuzvarwa kwavo kweiyo genetically based immune immune. ”, anotsanangura kudaro mudzidzisi Caterina Cancrini, mukuru wePrimary Immunodeficiencies Clinical and Research Unit yeComplex Operational Unit yeImmunology Hospital Clínico uye Vaccinology. "Kana kutanga kwezviratidzo kuchiri kwekutanga uye nekukasira, kudzokororwa kweallergic kuratidzwa kunopesana nekurapa kwechinyakare, hatifanirwe kubvisa mufananidzo weiyo genetically based immunodeficiency, iyo inofanirwa kusimbiswa nemiedzo chaiyo.".
Nekuda kwekunzwisisa kwemagadzirirwo ari kumashure kweichi chiitiko chisingazivikanwe kusvika zvino, zvave zvichibvira kufunga mamwe marapirwo, akadai Dupilumab, monoclonal antibody inovhara iyo IL-4 cytokine receptor. Icho chinhu chinokonzera-kuzvimba (chinowedzera muvanhu vaduku zvikuru), icho chakanga chatove inoshandiswa zvinobudirira muzvidzidzo zvine atopic dermatitis.
Vatsvagiri vepaBambino Gesù Hospital muRome vakapinda muchidzidzo chepasi rose, nekuda kweiyo primary immunodeficiency yakawanikwa, chirwere chisingawanzo geneti chinokonzera zviratidzo zvakafanana neizvo zveallergies asi zvakanyanya kuoma. Zvakakosha kukurumidza kuongororwa kuitira kuti dambudziko rigadziriswe nokukurumidza sezvinobvira.