Usana olusandul 'ukuzalwa luvela kwindawo engenazintsholongwane kodwa, njengoko ludlula kumjelo wokuzalwa luze lunxibelelane nehlabathi elingaphandle, luqala ukolonishwa ziintsholongwane ezahlukahlukeneyo ezithi kancinci kancinci zenze i-microbiota okanye iintyatyambo zamathumbu. Le microbiota ibaluleke kakhulu kuba impilo kubomi bayo bonke iya kuxhomekeka ikakhulu kukwahluka kwayo kunye nokusebenza. Iibhaktheriya ezikhoyo emathunjini zihambelana nokuphuhliswa kwamajoni omzimba, zikhusela kwizifo zamathumbu, izifo kunye nezifo ezahlukeneyo.
I-microbiota ayifani kuzo zonke iintsana. Oku kuyahluka ngokuxhomekeka kuhlobo lokuhanjiswa (kwilungu lobufazi okanye lokuhlinzwa), uhlobo lokondla (ukuncancisa okanye ibhotile), iiveki zokukhulelwa, amayeza kamama okanye usana, njl.
Kuphando olwenziwe sisazinzulu kwiBhunga eliPhakamileyo loPhando lwezeNzululwazi (CSIC), ziye zafundwa Iziphumo zokulawulwa kwezibulala-ntsholongwane ngexesha lokuzalwa komntwana kwisisu se-microbiota yeentsana ezizelwe ngexesha lobufazi. Iziphumo zibonisa ukuba lo mkhwa uqhelekileyo unokukhetha ukoloniyaliya ngenxa yeentsholongwane.
Ulawulo lwee-antibiotics kumama ngexesha lokubeleka yinto eqhelekileyo (malunga ne-30% yamatyala). Isetyenziswa njengeprophylaxis xa umama evumayo kuhlalutyo lwe-streptococcus, uhlobo lweebhaktheriya ezingabangeli monakalo phantsi kweemeko eziqhelekileyo kodwa ukuba, ukuba ifikelela emiphungeni, inokuba neziphumo ezibi kusana olusandul 'ukuzalwa. Kwizifundo zangaphambili, kwakusele kubonwe ukuba ukulawulwa kwee-antibiotics kubangele utshintsho kwi-microbiota yeentsana ezizelwe ngaphambi kwexesha. Ukulandela uphando lwamva nje, ezi ziphumo zigqithiselwe kubantwana abasisigxina. Ngokuka-Miguel Gueimonde, omnye wabaphandi be-CSIC, Impembelelo yonyango lwe-antibiotiki kwiintyatyambo zamathumbu kunye nokubonakala kweebhaktheriya ezithwala iizakhi zofuzo ezingapheliyo kufuneka ingqalelo ekhethekileyo.
Iqela labaphandi, kubandakanya oososayensi abavela kwiCentral University Hospital yaseAsturias kunye neDyunivesithi yaseParma (e-Itali), bahlalutye iisampuli zesto ukusuka kwiintsana ezingama-40 ezizeleyo ngokuziswa komfazi. Kwezi, i-18 yazalelwa ekuhanjisweni apho umama wanikwa ipenicillin njenge-antibacterial prophylaxis.
Ukulandelwa kwenziwa ngeenyanga ezintathu zokuqala zobomi beentsana kwaye, phakathi kwezinye iziphumo, a ukwehla kwentsholongwane yosapho IBifidobacteriaceae ubukho babo buluncedo emzimbeni. Kwangokunjalo, ukonyuka kweentsholongwane ezinokubangela isifo kunye nokunganyangeki kwiCampylobacter okanye uhlobo lweHelicobacter kwajongwa.
Ngokwabaphandi, uphononongo alufuni kuphelisa umkhuba wokulawula amayeza okubulala iintsholongwane, Kodwa ukulumkisa ngeziphumo zesibini kunye nokubeka iziseko zokusekwa kwezicwangciso ezijolise ekulungiseni olu tshintsho, ukuthanda ukuthanjiswa kunye nokusekwa kwe-microbiota yamathumbu osana.