Njengoba ngamunye UDisemba 21 namuhla wusuku lukazwelonke lwengane enomdlavuza. Lesi sinyathelo sazalwa sakhuthazwa yiSpain Federation of Parents of Children ngeCancer. ESpain, umdlavuza wezingane uthinta cishe izingane eziyi-1.100 XNUMX ngonyaka. Izindaba ezimnandi ukuthi ukufa komdlavuza ebuntwaneni kuncane kakhulu. Bangu amazinga okusinda ngemuva kweminyaka engu-5 yokwelashwa esondele ku-80%, futhi ifinyelele ku-100% kwezinye izinhlobo ezithile zezicubu.
Le mininingwane inikezwe yi-General Council of Pharmaceutical Colleges, ekhishwe embhalweni wayo Indawo Yezemithi 148. Umbiko uhlola i- izici zokwelashwa nokwelashwa kwamaqhubu avame kakhulu ezinganeni, ngaphezu kokubuyekeza indima yezokunakekelwa kwempilo kochwepheshe bezokwelapha.
Indima kasokhemisi ekwelapheni umdlavuza wezingane
Indima kasokhemisi ngu ukufaka isandla empilweni engcono yalezi ziguli. Usokhemisi ufaka isandla ekufundiseni iziguli zezingane futhi imindeni yenu nama-leukemias nama-lymphomas ezicini ezifana nokudla, ngoba izindlela ezithile zokwelapha kanye nalesi sifo kungadala ukungondleki. Izicubu ze-hematologic kanye nalezo zesistimu yezinzwa emaphakathi zivame kakhulu ngokuya ngomdlavuza wezingane. Cishe izingane ezingama-50% ezineminyaka engaphansi kwengu-15 ezinomdlavuza zine-leukemia.
Ekutholakaleni kokuqala, usokhemisi ungumlingani, ngoba ukuqala kokwelashwa kwama-leukemias kanye ne-lymphomas kuyisinqumo esinqumayo. Ezinye ze amafulegi abomvu osokhemisi angawabona Yilezi: umkhuhlane wemvelaphi engaziwa, ukwehla kwesisindo noma i-asthenia ephawulwe ngaphandle kwesizathu esibonakalayo, ukulimaza ngaphandle kwesizathu esikhonjiwe, ama-lymph node avuvukile, noma ukuvela "kwezigaxa" ...
Bayasiza futhi ukunciphisa ubungozi bokutheleleka, ukugcizelela ezinyathelweni ezifana nokugeza izandla, ukungena emanzini, ukuzivocavoca umzimba njalo nokulinganisela nokugwema izixuku ezindaweni ezivaliwe Ngesikhathi sokwenza umuthi, njengoba kusetshenziswa izidakamizwa ezahlukahlukene, umsebenzi kasokhemisi ubalulekile ukwenza ukulandelela nokuqapha kwemithi, ikakhulukazi maqondana nokwelashwa kwe-CAR-T.
Ukwelashwa kwe-CAR-T, kusengaphambili ekwelapheni umdlavuza wezingane
Ukuvela kwezindlela zokwelashwa ezibizwa nge-CAR-T ekwelapheni ama-leukemias nama-lymphomas kuvame kakhulu. Lolu hlobo lwezokwelapha, ngenxa yobunzima balo, lwenza lubaluleke kakhulu ukusebenzisana phakathi kwekhemisi lasesibhedlela nekhemisi lomphakathi, ukwenza ngcono ukuphathwa kwemitholampilo nokuqhubeka kokunakekelwa kwezingane.
Ucwaningo emkhakheni we-oncology, futhi ikakhulukazi kwi-oncology yezingane, lukhiqiza intuthuko ebalulekile. LUkwelashwa kwe-CAR-T uhlobo lwe-immunotherapy olusetshenziswa ngokuya ngokuguqulwa kofuzo kwama-lymphocyte. Lawa ngamangqamuzana abhekene nokulawula ukuphendula komzimba. Inhloso ukuthi bakwazi ukubona amangqamuzana omdlavuza njengakwamanye amazwe nokuwaqeda.
ESpain Izikhungo zokuqala zokukhuthaza leli su ezigulini zezingane yiMitholampilo Yesibhedlela kanye neSant Joan de Déu eBarcelona. NgoJuni 2020, iLa Paz University Hospital, ngokusebenzisa iPediatric Hemato-Oncology Service yayo, yabika ukuthi isikhiphe isiguli sokuqala sezingane eselashwa eMphakathini waseMadrid ngamaseli e-CAR-T, umfana oneminyaka engu-11 ubudala.
Izicelo zesevisi yemindeni
USilvana Briones, umfundi e-Autonomous University of Madrid (UAM) uthole umfundaze wokwakha iphrojekthi yobumbano yokuqwashisa ngomdlavuza wezingane nowentsha, ofaka usizo lwezengqondo kulabo abahlushwa yilo. Imayelana ne- uhlelo lokusebenza leselula le-Mi RiquezAPP. Lo mbono unembewu yawo kuphrojekthi yeRiqueza de Vivir, ephethwe yi-Aragon Association of Children with Cancer.
Isinyathelo sikaSilvana Briones, umfundi weBiochemistry, ube ngomunye wabaphumelele kwisayensi yeFord College Community Challenge Sponsor. Isicelo sizonikeza ngokuthakazelwayo mayelana nomdlavuza wezingane, ubufakazi obuvela ezigulini nasemindenini. Ngaphezu kwalokho, inesigaba sesayensi kanye nezingxoxo nabacwaningi. Ngayo ufinyelela ifayela le- inethiwekhi yamavolontiya ahlinzeka ngokusekelwa okukhethekile kwengqondo ezigulini nasemindenini yazo.
I-Los Izinzuzo zohlelo lokusebenza lobumbano zizoya ngokuphelele ezinhlanganweni zesiguli somdlavuza. Njengoba umthuthukisi womqondo echaza, inhloso ukunikela ngosizo losizo lwengqondo, olwesekelwa yiZingane ezineCancer Foundation.